Author

Adam Thomas

Imperial College LondonORCID 0000-0002-8780-8795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Thomas Lanyon‐HoggiD· 2 shared Alan ArmstrongiD· 1 shared Alistair N. HumeiD· 1 shared David J. ManniD· 1 shared Deborah A. Briggs· 1 shared Delia Brustur· 1 shared Edward W. TateiD· 1 shared Elena De VitaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Thomas Lanyon‐HoggORCID

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2 papers

Recent·Most cited

Discovery of stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction

Elena De Vita, Adam Thomas, Delia Brustur, Montse Tersa, Rita Petracca, Shradda Vadodaria, Deborah A. Briggs, Jack W. Houghton, Thomas Lanyon‐Hogg, Gregory B. Craven, Rhodri M. L. Morgan, Alan Armstrong, David J. Mann, Katharine M. Lodge, Alistair N. Hume, , Edward W. Tate

This paper develops the first cell-active covalent inhibitors of RAB27-effector interactions, showing enantioselectivity and improved potency over a previously reported toxic compound.

Journal of the American Chemical Society · Aug 3, 2026Peer-reviewedBiochemistry

Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in Escherichia coli

Tricia C.Y. Seow, Jacob D. Bradbury, Emilia K. Taylor, Ludwig G. Bauer, Madia Harvey, Hildur Hreidarsdottir, Soraya M. Saghbini, Yiqiao Wang, Adam Thomas, Patrícia Santos Barbosa, K. Huber, Georgia L. Isom, Thomas Lanyon‐Hogg

This study identifies YbaA as a new ciprofloxacin-binding protein in E. coli using AfBPP and validates its interaction through genetic and biophysical assays.

bioRxiv · Oct 16, 2025 · PreprintMicrobiology