Greg A. Weir

Precision cell-state silencing of injured afferents alleviates spontaneous neuropathic pain

The paper demonstrates that precision targeting of injured sensory neurons using gene therapy alleviates neuropathic pain in mice.

Deep FLASH-seq profiling of purified canine sensory neurons uncovers species-specific signatures relevant to pain and itch

The paper profiles canine sensory neurons using FLASH-seq to identify species-specific molecular signatures relevant to pain and itch, revealing both conserved and divergent features compared to human and mouse.

Macrophages amplify the spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain

Peripheral nerve injury results in a biased loss of sensory neuron sub-populations

This study shows that peripheral nerve injury preferentially eliminates specific DRG neuron subpopulations, particularly non-peptidergic nociceptors, and links this loss to neurotrophic support.

Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons

The paper uses single-nucleus RNA sequencing to identify five distinct classes of anterolateral system neurons in the adult mouse spinal cord and their laminar distribution.

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

This study shows that NPY-expressing inhibitory interneurons in the spinal dorsal horn reduce pain and itch behaviors, suggesting they are potential targets for treating pathological pain and itch.

Molecular and cellular correlates of human nerve regeneration: ADCYAP1 encoding PACAP enhances sensory neuron outgrowth

The paper identifies ADCYAP1 (PACAP) as a key molecule enhancing sensory neuron outgrowth in human nerve regeneration using carpal tunnel syndrome as a model.