Mitchell L. Drumm

This study shows that CFTR dysfunction in intestinal epithelial cells promotes E. coli expansion and increased intestinal permeability in cystic fibrosis.

This paper develops a nonviral, ultrasound-triggered gene delivery platform using cationic nanobubbles that achieve efficient, site-specific gene expression in vitro and in vivo.

The paper uses 4D CFD simulations to study hemodynamics and tissue mechanics in the cardiac outflow tract during development, revealing correlations between wall shear stress and tissue extension.

This study develops a platform to screen and rescue multiple splicing mutations using a single exon-specific U1 snRNA, showing effectiveness in rescuing 3 and 5 splice site mutations in CFTR exon 18.