Killian Hurley

This study develops an iPSC platform to test CFTR modulators in cystic fibrosis patients with rare mutations, showing genotype-specific responses to drugs.

This paper introduces CoSpar, a computational method that integrates single-cell genomics with lineage tracing to infer cell dynamics, revealing previously undetected fate biases in hematopoiesis, reprogramming, and differentiation.

The paper maps cell fate trajectories of human PSC-derived distal lung progenitors using scRNA-seq and identifies developmental plasticity regulated by Wnt signaling.