Author

Linda Karlsson

Lund UniversityORCID 0000-0002-0630-772XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:imaging· 3 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Oskar HanssoniD· 4 shared Erik StomrudiD· 3 shared Jacob W. VogeliD· 3 shared Niklas MattssoniD· 3 shared Alexa Pichet BinetteiD· 2 shared Olof T. Strandberg· 2 shared Sebastian PalmqvistiD· 2 shared the Alzheimer’s Disease Neuroimaging Initiative· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersNeuroscience

Oskar HanssonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease

Toomas Erik Anijärv, Rik Ossenkoppele, Ruben A Smith, Alexa Pichet Binette, Lyduine Eisa Collij, Hamid Behjat, Jonathan Ö. Rittmo, Linda Karlsson, Khazar Ahmadi, Olof T. Strandberg, the Alzheimer’s Disease Neuroimaging Initiative, Michael Walter Weiner, Paul S. S Aisen, Ronald Carl Petersen, Clifford R. Jack, , Oskar Hansson

The paper investigates whether hemispheric asymmetry in tau pathology in Alzheimer's disease is linked to reduced inter-hemispheric connectivity or asymmetric amyloid-beta distribution, finding a strong association with amyloid-beta laterality.

Nature Communications · Sep 5, 2025Peer-reviewedNeuroscience

Personalised Regional Modelling Predicts Tau Progression in the Human Brain

Pavanjit Chaggar, Jacob W. Vogel, Alexa Pichet Binette, Travis Thompson, Olof T. Strandberg, Niklas Mattsson, Linda Karlsson, Erik Stomrud, Saâd Jbabdi, Stefano Magon, Gregory Klein, the Alzheimer’s Disease Neuroimaging Initiative, Oskar Hansson, Alain Goriely

The paper develops a mechanistic model of tau protein dynamics using PET data to predict regional tau accumulation and disease progression stages in Alzheimer's patients.

PLoS Biology · Jul 21, 2025Peer-reviewedNeuroscience

Synapse protein signatures in cerebrospinal fluid and plasma predict cognitive maintenance versus decline in Alzheimers disease

Hamilton Se‐Hwee Oh, Deniz Yagmur Urey, Linda Karlsson, Zeyu Zhu, Yuanyuan Shen, Amelia Farinas, Jigyasha Timsina, Michael R. Duggan, Jingsha Chen, Ian Hunter Guldner, Nader Morshed, Chengran Yang, Daniel Western, Muhammad Ali, Yann Le Guen, , Tony Wyss‐Coray

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

Nature Medicine · Mar 31, 2025Peer-reviewedNeuroscience✦ In-depth digest

Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases

Linda Karlsson, Jacob W. Vogel, Ida Arvidsson, Kalle Åström, Shorena Janelidze, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Niklas Mattsson, Oskar Hansson

The paper identifies reference proteins in cerebrospinal fluid that improve the accuracy and interpretability of biomarkers for brain diseases by accounting for inter-individual variability.

Nature Communications · May 1, 2024Peer-reviewedNeuroscience