Jia Yi

The paper maps variant, enhancer, and gene function in primary human CD4+ T cells by combining Perturb-seq of regulatory elements and genes, identifying CRE-gene pairs and linking variants to disease-related programs.

This paper investigates how influenza A virus RNA polymerase (FluPol) interacts with host chromatin during infection, showing it targets regulatory elements of immune response genes and interferes with transcription processes.

The paper identifies HP1γ's RNA binding activity in transcribed genes and shows it enhances splicing fidelity by tethering pre-mRNA to chromatin through intronic repeats.