Nadja Lehmann

This paper introduces a novel mouse reporter line for live imaging of axon initial segments, enabling real-time study of AIS plasticity in vivo.

The paper shows that mouse cortical neurons can change their axon origin from somatic to dendritic and vice versa in response to network activity changes.

The paper identifies axon-carrying dendrites (AcDs) in neocortical pyramidal neurons, showing higher prevalence in non-primates compared to monkeys and humans.

The paper shows sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex, with sensory deprivation increasing AIS length and excitability, while enrichment shortens AIS and reduces action potential generation.