Maren Engelhardt

This study examines nanoscale changes in synaptic proteins in human temporal lobe epilepsy, finding increased AMPA receptor density and altered calcium channel organization in specific synapse types.

The paper identifies HIF1α as a regulator of CaV3.2 expression, linking hypoxia to neuronal hyperexcitability and epileptogenesis.

The paper shows that chronic inactivity does not broadly affect action potentials in neocortical neurons but does in hippocampal neurons under specific conditions.

This paper introduces a novel mouse reporter line for live imaging of axon initial segments, enabling real-time study of AIS plasticity in vivo.

This study maps the structural variability of axon initial segments in mouse hippocampal pyramidal neurons and shows how this variability affects neuronal response patterns.

The paper shows that mouse cortical neurons can change their axon origin from somatic to dendritic and vice versa in response to network activity changes.

The paper identifies acute and lasting molecular, cellular, and behavioral changes in mice after single-dose ethanol intoxication using proteomics and imaging.

The paper identifies axon-carrying dendrites (AcDs) in neocortical pyramidal neurons, showing higher prevalence in non-primates compared to monkeys and humans.

The paper shows sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex, with sensory deprivation increasing AIS length and excitability, while enrichment shortens AIS and reduces action potential generation.