Christian Thome

HIF1α-dependent induction of the T-Type calcium channel CaV3.2 mediates hypoxia-induced neuronal hyperexcitability

The paper identifies HIF1α as a regulator of CaV3.2 expression, linking hypoxia to neuronal hyperexcitability and epileptogenesis.

Defined human tri-lineage brain microtissues

The paper develops human tri-lineage brain microtissues composed of neurons, astrocytes, and microglia, showing they recapitulate cell-cell interactions and pathological processes.

Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice

This paper introduces a novel mouse reporter line for live imaging of axon initial segments, enabling real-time study of AIS plasticity in vivo.

Variability of axon initial segment geometry and its impact on hippocampal pyramidal cell function

This study maps the structural variability of axon initial segments in mouse hippocampal pyramidal neurons and shows how this variability affects neuronal response patterns.

Axon onset remodeling in response to network activity in mouse cortical neurons

The paper shows that mouse cortical neurons can change their axon origin from somatic to dendritic and vice versa in response to network activity changes.

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.

This study integrates human iPSC-derived microglia into midbrain organoids, enhancing neuronal maturation and functionality through effects on synaptic remodeling and excitability.