Claudio Acuna

This study identifies Paralemmin-2 as a component of axon initial segments and nodes of Ranvier, showing its role in modulating the submembrane cytoskeleton and neuronal excitability.

This study shows KCNQ1 regulates human neuronal development by affecting cell adhesion, mitochondrial function, and insulin signalling pathways.

This study identifies the role of the liprin-α/RIM complex in synaptic transmission through liquid-liquid phase separation, showing its impact on calcium channel distribution and vesicle release.

This study identifies Paralemmin-1 as a regulator of the neuronal submembrane cytoskeleton MPS, showing it enhances periodicity and is essential for its structure and function.

This paper introduces a novel mouse reporter line for live imaging of axon initial segments, enabling real-time study of AIS plasticity in vivo.

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

The paper identifies hypothalamic preoptic neurons that develop warm-sensitive activity during heat acclimation, enabling heat tolerance through cell-autonomous mechanisms.

This study shows that layer 5 and 6 neurons in the primary somatosensory cortex modulate sensory gain and nociceptive behavior in opposite ways.

Fear-Mouse Tracker (FMT) is an open-source MATLAB pipeline that quantitatively analyzes mouse defensive behaviors using DeepLabCut coordinates.

The paper identifies bi-allelic variants in TSPOAP1 as a cause of autosomal recessive dystonia, showing different clinical presentations based on variant type.