Wen Zhang

This paper develops an EpCAM-targeted L-DNA nanostructure for targeted doxorubicin delivery in TNBC, showing improved stability and reduced cytotoxicity in normal cells.

This paper develops L-DNA nanocubes for targeted drug delivery, showing improved stability and therapeutic efficacy compared to D-DNA nanocubes.

This paper uses {lambda}-dynamics to predict RNA binding preferences of human Pumilio, including modified RNAs, showing high accuracy compared to experimental data.

This paper constructs a mirror-image RNA nanostructure to improve biostability and drug delivery efficiency by conjugating siRNA and chemotherapy agents with enhanced endosomal escape.

This paper uses in silico λ-dynamics to predict antibody binding specificities to RNA modifications, showing high agreement with experimental results.

This study selects a 2-fluoro modified mirror-image RNA aptamer targeting a viral frameshift element with opposite chirality, showing improved stability and moderate binding affinity.