Francesco Nicola Carelli

The paper identifies activation of the innate immune stress pathway as a mechanism linking heterochromatin dysfunction to pathological phenotypes in C. elegans and human cells.

The paper identifies lin-15A as a Licenser that facilitates transdifferentiation by antagonizing identity safeguarding mechanisms in C. elegans.

This study constructs a lineage-resolved single-cell multimodal atlas of early C. elegans development, revealing genomic dynamics and zygotic genome activation mechanisms.

This study identifies the role of SPT2 in chromatin structure and function across Metazoa, showing its importance in germline development and chromatin accessibility.

The paper shows that transposon expansions in Caenorhabditis nematodes rewired germline transcriptional regulation, with one third of germline-specific promoters co-opted from MITEs.

The paper shows that DREAM complex represses distinct gene targets in C. elegans through cooperation with different THAP domain proteins, LIN-36 and LIN-15B, which use separate mechanisms.

The paper identifies regulatory elements that have switched function between enhancers and promoters across mammalian species and shows how these changes may drive evolutionary innovations.