Chengshui Chen

Exploring the Antifibrotic Potential of the heparan sulfate mimetic OTR4120: Insights from Preclinical Models

This study evaluates the antifibrotic effects of OTR4120 in lung fibrosis models, showing reduced collagen deposition and fibroblast activation.

Characterization of a novel Fgf10CreERT2 knock-in mouse line targeting postnatal lung Fgf10 lineages

The paper describes the development and validation of a new Fgf10CreERT2 mouse line (Fgf10Ki-v2) that effectively targets Fgf10-positive cells in adult lungs, overcoming limitations of an earlier version.

Characterization in mice of the stromal niche maintaining AT2 stem cell self-renewal in homeostasis and disease

This study identifies rMC-Sca1PosFgf10Pos cells as a functional population critical for maintaining AT2 stem cell self-renewal and differentiation in mice, with implications for fibrosis and COVID-19 pathogenesis.

A critical role for miR-142 in alveolar epithelial lineage formation

This study identifies miR-142's role in regulating alveolar epithelial cell lineage formation through interactions with the glucocorticoid and p300 signaling pathways.

A smooth muscle-like niche facilitates lung epithelial regeneration

This study identifies a repair-supportive mesenchymal cell population critical for lung epithelial regeneration through single-cell RNA sequencing and lineage tracing.