Thomas W Braun

The paper investigates how FUS loss in fibroblasts affects transcriptional elongation and senescence in IPF, finding that reduced FUS levels increase Pol II activity and fibrosis-related gene expression.

This study identifies FAHD1 as a critical regulator of mitochondrial function and cardiomyocyte maturation, showing its deficiency impairs respiration, disrupts sarcomere organization, and leads to cardiac dysfunction.

This study identifies REG3β as a factor that removes aged neutrophils after myocardial infarction, promoting inflammation resolution and cardiac repair.

This study identifies ZBTB16 as a critical regulator of endothelial function in aging, showing its protective role against cardiac dysfunction through suppression of pro-fibrotic signaling.

This paper describes an optimized sACE2-Fc decoy that redirects SARS-CoV-2 to phagocytes, achieving complete prophylactic protection in mice.

This study shows that inhibiting Runx1 protects against heart failure with preserved ejection fraction in mice by improving diastolic function and reducing hypertrophy and pulmonary edema.

The paper shows that nuclear miR-9 is required for chromatin features and promoter-super-enhancer looping during TGFB1-induced transcriptional activation.

The paper identifies a conserved gene signature associated with right ventricular failure in both rat and human hearts through transcriptomic analysis and validation.

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.

multicrispr is a gRNA design tool that enables efficient and specific gRNA creation for CRISPR-based applications like Prime Editing and large-scale screening.

TOBIAS enables genome-wide analysis of TF binding dynamics using ATAC-seq data, revealing complex TF interactions during zygotic genome activation in humans and mice.

This study identifies SirT7's dual role as a deacetylase and mADPRT enzyme, showing its regulation of glucose starvation response via interaction with macroH2A1.1.

This study identifies a repair-supportive mesenchymal cell population critical for lung epithelial regeneration through single-cell RNA sequencing and lineage tracing.

The paper uses single-cell RNA-seq and ATAC-seq to study cardiac progenitor cell fate transitions, identifying roles for Isl1 and Nkx2-5 in lineage commitment and gene regulatory networks.