Julio Cordero

Cell-specific FUS loss enhances ageing-associated transcriptional elongation in lung fibrosis

The paper investigates how FUS loss in fibroblasts affects transcriptional elongation and senescence in IPF, finding that reduced FUS levels increase Pol II activity and fibrosis-related gene expression.

Loss of cardiomyocyte eukaryotic elongation factor 1A2 in mice triggers cardiomyopathy due to defective proteostasis

This study shows that loss of eEF1A2 in cardiomyocytes causes cardiomyopathy through proteostasis defects, and mTORC1 inhibition can reverse the condition.

Erlotinib induces 3D genome rearrangements in lung cancer cells activating tumor suppressor genes through FOXA2-bound Epromoters

3D genome organization during TGFB-induced transcription requires nuclear microRNA and G-quadruplexes

The paper shows that nuclear miR-9 is required for chromatin features and promoter-super-enhancer looping during TGFB1-induced transcriptional activation.

Endothelial cell-derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate pathological cardiac remodeling via intercellular crosstalk

This study identifies Gadlor1 and Gadlor2 as endothelial cell-derived lncRNAs that worsen cardiac remodeling through EV-mediated crosstalk with cardiomyocytes.

Rnf20 shapes the endothelial control of heart morphogenesis and function

This study identifies Rnf20's role in regulating cardiac morphogenesis and function through endothelial mechanisms, revealing its impact on extracellular matrix dynamics and angiocrine signaling.

Positioning of nucleosomes containing γ-H2AXprecedes active DNA demethylation and transcription initiation

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.

A critical role for miR-142 in alveolar epithelial lineage formation

This study identifies miR-142's role in regulating alveolar epithelial cell lineage formation through interactions with the glucocorticoid and p300 signaling pathways.