Tiago Maié

This paper identifies PDE3A-SLFN12 molecular glues as a novel therapeutic target for KIT D816V-driven mast cell malignancies, showing their efficacy in killing multiple KIT D816V cell types and synergy with tyrosine kinase inhibitors.

The paper estimates effective population size (Ne) of western chimpanzees in Guinea-Bissau using genetic data to inform conservation strategies.

PILOT-GM-VAE analyzes single cell disease atlases to perform sample-level clustering, trajectory inference, and batch correction using Gaussian Mixture Variational Autoencoders with optimal transport.

This study investigates the postnatal maturation of the small intestinal epithelium, identifying developmental regulators as key drivers over microbiota effects.

scACCorDiON clusters patient-specific cell-cell communication graphs using optimal transport, improving disease status prediction in scRNA-seq data.

This study investigates how life history traits affect genetic diversity dynamics in refugium populations during range expansion and contraction.

The paper identifies aberrant DNA methylation in cancer-associated fibroblasts across multiple cancer types and links these changes to patient prognosis.

CimpleG identifies small CpG methylation signatures for cell type classification and deconvolution, performing efficiently with single CpG sites per cell type.

DECONbench benchmarks deconvolution methods for quantifying tumor cell-type heterogeneity by providing datasets, tools, and performance evaluation.

The paper demonstrates that targeted DNA methylation analysis at individual CpG sites can accurately deconvolve cellular composition in human tissues.