Martin Zenke

This paper develops a standardized framework for generating sensory neurons from human iPSCs using NGN1, improving differentiation efficiency and functional maturation for disease modeling and drug screening.

This paper identifies PDE3A-SLFN12 molecular glues as a novel therapeutic target for KIT D816V-driven mast cell malignancies, showing their efficacy in killing multiple KIT D816V cell types and synergy with tyrosine kinase inhibitors.

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

This study identifies JAK2V617F zygosity-specific vascular changes in MPN and shows IFNα inhibits EndMT, offering a novel antifibrotic mechanism.

RGT is a Python package for integrative analysis of regulatory genomics data, offering tools for peak calling, binding site prediction, and regulatory factor association.

The paper shows that Lrig1 and Wnt-Lef1 signaling in keratinocytes control the spatial segregation of melanocytes and immune cells in murine tail epidermis.

scOpen improves downstream analysis of sparse scATAC-seq data by imputing open chromatin regions, revealing regulatory changes in kidney fibrosis.

The paper introduces HINT-ATAC, a method for identifying transcription factor binding sites in ATAC-seq data by addressing protocol artifacts and using probabilistic models.

This study shows that specific DNMT3A transcripts have distinct epigenetic and functional effects on hematopoietic differentiation and are linked to AML outcomes.