Author

Brandon Cho

University of TorontoORCID 0000-0003-4889-5619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Miguel Ramalho‐SantosiD· 4 shared Giacomo FurlaniD· 3 shared Évelyne CollignoniD· 2 shared Abdul Rahman· 1 shared Andrew J.K. WilliamsoniD· 1 shared Andrew Mazzanti· 1 shared Anthony David WhettoniD· 1 shared Aydan Bulut-KarslıoğluiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersDevelopmental Biology

Miguel Ramalho‐SantosORCID

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4 papers

Recent·Most cited

Developmental BiologyDevelopmental CellPeer-reviewedAug 4, 2026

Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism

Giacomo Furlan, Sylvia-Bryn Martin, Brandon Cho…·Miguel Ramalho‐Santos

The paper identifies Nodal/Smad2 signaling as essential for sustaining embryonic diapause by repressing Pparg-mediated lipid metabolism.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologyOncogenePeer-reviewedMar 7, 2026

CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer

Brandon Cho, Giacomo Furlan, Peter Lin…·Miguel Ramalho‐Santos

The paper identifies CHD1 as a synthetic lethal target in MYC-driven breast cancer, showing that its loss suppresses tumor growth and induces cell death in MYC-overexpressing models.

DOI 10.1038/s41388-026-03709-9

humanbulk RNA-seq

𝕏 PostBluesky

Developmental BiologybioRxivPreprintJan 30, 2023

m6A RNA methylation orchestrates transcriptional dormancy during developmental pausing

Évelyne Collignon, Brandon Cho, Julie Fothergill-Robinson…·Miguel Ramalho‐Santos

This study identifies m6A RNA methylation by Mettl3 as essential for developmental pausing in mice by maintaining transcriptional dormancy through mRNA destabilization and suppression of N-Myc.

1 citation

mousebulk RNA-seq

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Molecular BiologyNature CommunicationsPeer-reviewedAug 11, 2021

Chd1 regulates repair of promoter-proximal DNA breaks to sustain hypertranscription in embryonic stem cells

Aydan Bulut-Karslıoğlu, Hu Jin, Yun‐Kyo Kim…·Miguel Ramalho‐Santos

This study identifies Chd1's role in repairing DNA breaks in embryonic stem cells, showing its importance in maintaining hypertranscription during development.

24 citations

mouseDNA methylation

𝕏 PostBluesky