Author

Giacomo Furlan

University of TorontoORCID 0000-0002-6147-8150Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Organism:human· 2

Frequent Co-Authors

Miguel Ramalho‐SantosiD· 4 shared Brandon ChoiD· 3 shared Évelyne CollignoniD· 2 shared Abdul Rahman· 1 shared Andrew Mazzanti· 1 shared Aurélia HuygheiD· 1 shared Claire ChazaudiD· 1 shared Cloé RognardiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersDevelopmental Biology

Miguel Ramalho‐SantosORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism

Giacomo Furlan, Sylvia-Bryn Martin, Brandon Cho, Ying Yu Ng, Sarah A. McClymont, Abdul Rahman, Elizabeth J. Robertson, Évelyne Collignon, Miguel Ramalho‐Santos

The paper identifies Nodal/Smad2 signaling as essential for sustaining embryonic diapause by repressing Pparg-mediated lipid metabolism.

Developmental Cell · Aug 4, 2026Peer-reviewedDevelopmental Biology

CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer

Brandon Cho, Giacomo Furlan, Peter Lin, Mélissa Shen, Kirti Mittal, Andrew Mazzanti, Linda Z. Penn, Miguel Ramalho‐Santos

The paper identifies CHD1 as a synthetic lethal target in MYC-driven breast cancer, showing that its loss suppresses tumor growth and induces cell death in MYC-overexpressing models.

Oncogene · Mar 7, 2026Peer-reviewedCancer Biology

A ligand/receptor trafficking clock governs self-renewal and abscission dynamics in pluripotent stem cells

Debora Libetti, Noémie Combémorel, Emma Fraimbault, Marie Lantelme, Xavier Gaume, Emile Zakiev, Yann Tapponnier, Aurélia Huyghe, Giacomo Furlan, Marion Coudurier, Léo Claret, Cloé Rognard, Serife Akguel, Serife Akguel, Hector Hernandez-vargas, , Fabrice Lavial

The paper identifies a ligand/receptor trafficking clock in pluripotent stem cells that regulates self-renewal and abscission dynamics through cyclic turnover of Netrin-1 and its receptors.

bioRxiv · Dec 23, 2025 · PreprintCell Biology

m6A RNA methylation orchestrates transcriptional dormancy during developmental pausing

Évelyne Collignon, Brandon Cho, Julie Fothergill-Robinson, Giacomo Furlan, Robert L. Ross, Patrick A. Limbach, Miguel Ramalho‐Santos

This study identifies m6A RNA methylation by Mettl3 as essential for developmental pausing in mice by maintaining transcriptional dormancy through mRNA destabilization and suppression of N-Myc.

bioRxiv · Jan 30, 2023 · PreprintDevelopmental Biology