Author

Charles Lau

University of British ColumbiaORCID 0000-0003-4909-8144Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Peter W. ZandstraiD· 2 shared Ross D. JonesiD· 2 shared Yale S. MichaelsiD· 2 shared Ali Murtaza· 1 shared Carla ZimmermaniD· 1 shared Diana WuiD· 1 shared Divy RavaliD· 1 shared Esther JangiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBioengineering

Peter W. ZandstraORCID

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2 papers

Recent·Most cited

BioengineeringCell stem cellPeer-reviewedJan 1, 2026

Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells

Ross D. Jones, Kevin Salim, Laura N Stankiewicz…·Peter W. Zandstra

This study shows how to generate CD4+ T cells from pluripotent stem cells by controlling Notch and T cell receptor signaling, enabling clonally diverse and expandable cells that can differentiate into helper cell types.

9 citationstop 1%

humanexperimental assay

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Synthetic BiologybioRxivPreprintNov 5, 2021

Discrete-to-analog signal conversion in human pluripotent stem cells

Laura Prochazka, Yale S. Michaels, Charles Lau…·Peter W. Zandstra

The paper develops synthetic gene circuits in human pluripotent stem cells that convert discrete cell states into analog signals by integrating miRNAs with miSFITs for controlled effector protein production.

1 citation

humanCRISPR screen

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