Author

Laura Prochazka

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Peter W. ZandstraiD· 2 shared Alice VickersiD· 1 shared Blaise LouisiD· 1 shared Charles LauiD· 1 shared Curtis M. WoodfordiD· 1 shared Daniel Aguilar‐HidalgoiD· 1 shared David Becerra‐AlonsoiD· 1 shared Davide DanoviiD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersSynthetic Biology

Peter W. ZandstraORCID

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2 papers

Recent·Most cited

Discrete-to-analog signal conversion in human pluripotent stem cells

Laura Prochazka, Yale S. Michaels, Charles Lau, M. Mona Siu, Ting Yin, Diana Wu, Esther Jang, Ross D. Jones, Mercedes Vázquez‐Cantú, Penney M. Gilbert, Himanshu Kaul, Yaakov Benenson, Peter W. Zandstra

The paper develops synthetic gene circuits in human pluripotent stem cells that convert discrete cell states into analog signals by integrating miRNAs with miSFITs for controlled effector protein production.

bioRxiv · Nov 5, 2021 · PreprintSynthetic Biology

High-throughput micro-patterning platform reveals Nodal-dependent dissection of peri-gastrulation-associated versus pre-neurulation associated fate patterning

Mukul Tewary, Dominika Dziedzicka, Joel Östblom, Laura Prochazka, Nika Shakiba, Tiam Heydari, Daniel Aguilar‐Hidalgo, Curtis M. Woodford, Elia Piccinini, David Becerra‐Alonso, Alice Vickers, Blaise Louis, Nafees Rahman, Davide Danovi, Mieke Geens, , Peter W. Zandstra

The paper develops an in vitro platform to study fate patterning in hPSCs, revealing Nodal-dependent switches between gastrulation and neurulation-associated gene profiles.

PLoS Biology · Oct 21, 2019Peer-reviewedDevelopmental Biology