Sarah A. Shoichet

The paper investigates the structural and functional differences between shaft and spine synapses, finding that shaft synapses are less stable and more responsive to activity changes.

This study shows JNK regulates SAP102 and kainate receptor dynamics in dendritic spines, impacting synaptic function and cognitive development.

The paper identifies MPP2 as a scaffold protein that links GABAA receptors to the postsynaptic density through super-resolution imaging and mass spectrometry.

The paper shows that binding of PDZ3 ligands to PSD-95's third PDZ domain alters its SH3-GK domain conformation, affecting complex formation with interactors like Gnb5.

This study investigates the role of CNK2 in neurons, showing it modulates PSD size and directs TNIK localization, which is important for dendritic spine growth and maintenance.

This study shows Shank2-/- mice have defective synapse maturation and enhanced synaptic plasticity, providing a mechanistic explanation for increased long-term potentiation.