Author

Christopher A. Natale

ORCID 0000-0003-4949-3849Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Organism:rat· 1

Frequent Co-Authors

Allan K. N. AlencariD· 1 shared Carolyn L. BayeriD· 1 shared Christopher Kent ArnattiD· 1 shared Cristina Aguirre‐PortolésiD· 1 shared Gabriella C. Pridjian· 1 shared Israel OlayideiD· 1 shared John T. SeykoraiD· 1 shared Kenneth F. Swan· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Allan K. N. AlencarORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintApr 1, 2025

Pregnancy-Dependent Cardioprotection via GPER Activation in Dahl Salt-Sensitive Rats

Allan K. N. Alencar, Kenneth F. Swan, Mistina M. Manoharan…·Carolyn L. Bayer

This study shows that GPER agonist LNS8801 improves cardiac function in pregnant Dahl SS/Jr rats but not virgin rats, highlighting pregnancy-specific cardioprotective effects.

DOI 10.1101/2025.04.01.646468

ratimaging

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Cancer BiologyCancer Research CommunicationsPeer-reviewedMar 11, 2025

LNS8801: An enantiomerically pure agonist of the G protein-coupled estrogen receptor suitable for clinical development

Christopher A. Natale, Sophia Mercado, Richard Zhuang…·Todd W. Ridky

This paper identifies LNS8801, a pure enantiomer of G-1 that acts as a GPER agonist, showing cancer suppression in preclinical models and potential as a therapeutic with a predictive biomarker.

10 citationstop 4%

humanexperimental assay

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