Sherry Ralls

The paper functionally characterizes human PRDM9 alleles to show that despite sequence diversity, most alleles function similarly, while rare variants show extreme DNA binding effects.

The paper identifies pachytene piRNAs as precise gene regulators during meiosis, showing they target specific mRNAs through near-perfect complementarity.

The paper identifies MNX1-bound loci in motor neurons and shows MNX1 restrains pan-neuronal gene expression.

ZFP661 blocks cohesin trapping by CTCF and increases protocadherin diversity for proper cortical dendritic arborization.

This study identifies ZCWPW1 as a dual histone methylation reader essential for meiotic DSB repair in vertebrates, showing its co-expression and co-evolution with PRDM9.

The paper shows that deleting large KRAB-ZFP gene clusters in mice leads to retrotransposon activation, indicating most KRAB-ZFPs are non-essential for transposon suppression.