Gary K. Owens

Dual Lineage Tracing Identifies Cellular Mechanisms Underlying Radiation-Associated Changes in Atherosclerotic Lesion Composition

This study uses dual lineage tracing to show irradiation reduces SMC investment in atherosclerotic lesions and increases EC-derived cells, leading to reduced plaque stability.

Dietary depletion of glutamine is atheroprotective

This study shows that dietary glutamine restriction reduces atherosclerotic plaque rupture mortality by promoting fibrotic smooth muscle cell phenotypes in mice.

Identification of endothelial-to-mesenchymal transition gene signatures in single-cell transcriptomics of human atherosclerotic tissue

The paper identifies gene signatures of endothelial-to-mesenchymal transition in human atherosclerotic tissue using combined in vitro and single-cell transcriptomic data.

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.