Hans‐Georg Sprenger

Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites

The paper constructs a multi-tissue lysosomal metabolite atlas in mice, revealing age-related accumulation of glycerophosphodiesters and cystine, linked to lysosomal storage disorders, and shows caloric restriction mitigates these changes in some tissues.

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L

This study identifies YME1L as a mitochondrial protease that regulates metabolic state transitions in adult neural stem cells, ensuring self-renewal and preventing premature differentiation.