Author

Karnika Bhardwaj

University of California, San FranciscoORCID 0009-0000-1769-0210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Allan I. BasbaumiD· 2 shared Brian K. ShoichetiD· 2 shared Aashish ManglikiD· 1 shared Brian J. BenderiD· 1 shared Bryan L. RothiD· 1 shared Chase M. WebbiD· 1 shared Christian B. BillesbølleiD· 1 shared Hye Jin KangiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

Allan I. BasbaumORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 30, 2025

Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia

Krishnashish Bose, Karnika Bhardwaj, Su Guo

The paper identifies a neural mechanism in dopamine-deficient zebrafish linking stress-induced sensory processing to motor control through hyperactive brain regions.

DOI 10.1101/2025.06.30.662454

zebrafishimaging

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BiophysicsbioRxivPreprintJan 9, 2025

Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects

Seth F. Vigneron, Shohei Ohno, Joao M. Braz…·Brian K. Shoichet

The paper screens 14.6 million virtual isoquinuclidines against opioid receptors to identify dual antagonists-inverse agonists with reduced withdrawal effects compared to naloxone.

3 citations

mousestructural biology

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Pharmacology & ToxicologybioRxivPreprintOct 25, 2023

Structure-Based Discovery of a NPFF1R Antagonist with Analgesic Activity

Brian J. Bender, Julie E. Pickett, João M. Bráz…·Brian K. Shoichet

This paper identifies a selective NPFF1R antagonist with analgesic properties, showing enhanced pain relief when combined with morphine and reduced side effects.

5 citations

mouseproteomics

𝕏 PostBluesky