João M. Bráz

This study identifies meningeal regulatory T cells (mTregs) expressing enkephalin that modulate mechanical pain sensitivity in female mice via a sex hormone-dependent opioid receptor mechanism.

The paper shows that overexpression of tetracycline transactivator in keratinocytes causes neuropathic itch in mice, which can be reversed by inhibiting Gi signaling or ablating TRPV1 neurons.

The paper identifies molecularly diverse spinal and trigeminal projection neurons involved in pain and itch, revealing distinct subsets and their functional roles.