Author

Ai Tian

Great Ormond Street HospitalORCID 0009-0000-1849-0624Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Julien MuffatiD· 2 shared Yun LiiD· 2 shared Aditi Aggarwal· 1 shared Afrin Bhattacharya· 1 shared Brett TrostiD· 1 shared Chaoying Long· 1 shared Craig A. SmibertiD· 1 shared Elizabeth RadleyiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Julien MuffatORCID

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2 papers

Recent·Most cited

BioinformaticsNature CommunicationsPeer-reviewedAug 19, 2026

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

Nuo Xu, Katherine M Rynard, Elizabeth Radley…·Shreejoy J. Tripathy

The paper generates a high-resolution proteogenomic atlas of human neuronal development using long-read RNA sequencing and proteomics, revealing novel isoforms and their role in neurodevelopmental risk mechanisms.

1 citation

humanlong-read sequencing

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NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedFeb 12, 2026

ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation

Navroop K. Dhaliwal, Octavia Yifang Weng, Ai Tian…·Yun Li

This study identifies the ARP2/3 complex as a downstream effector of mTORC1 and mTORC2 hyperactivation in PTEN-deficient neural cells, showing its inhibition can rescue disease phenotypes.

1 citation

humanexperimental assay

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