Yun Li

The paper generates a high-resolution proteogenomic atlas of human neuronal development using long-read RNA sequencing and proteomics, revealing novel isoforms and their role in neurodevelopmental risk mechanisms.

This study identifies GSK3-dependent phosphorylation of BNIP3 as a molecular switch that activates mitophagy by promoting WIPI protein recruitment.

This study identifies the ARP2/3 complex as a downstream effector of mTORC1 and mTORC2 hyperactivation in PTEN-deficient neural cells, showing its inhibition can rescue disease phenotypes.

The paper develops a cell type-agnostic model to predict developmental age from transcriptomes, achieving high accuracy across human brain datasets and organoids.

FAST-STEM accelerates human pluripotent stem cell engineering by enabling rapid transgene integration and differentiation into multiple cell types.

origamiFISH enables label-free, single-molecule detection of DNA origami nanostructures in cells and tissues, revealing cell-type and shape-specific uptake patterns at low concentrations.

This study shows that ZIKV infects neural progenitors, astrocytes, and microglia-like cells, with microglia acting as viral reservoirs and facilitating infection of the fetal brain.