Author

Zhiyuan Cheng

Gladstone InstitutesORCID 0009-0000-3474-2422Unclaimed ORCID profile · follow to get notified of new preprints

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Zhiyuan Cheng3 papers · Chinese Academy of Sciences

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Alan AshworthiD· 1 shared Arushi Singhal· 1 shared Chenglong XiaiD· 1 shared Daniel Rosas-Rivera· 1 shared Giselle C. LeeiD· 1 shared Hesong HaniD· 1 shared Huadong CheniD· 1 shared Jared ThompsoniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Alan AshworthORCID

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1 paper

Recent·Most cited

Cell BiologyNaturePeer-reviewedJun 8, 2026

Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding

Jingkun Zeng, Zhiyuan Cheng, Huadong Chen…·Jennifer A. Doudna

This paper develops a method to selectively kill cancer cells with TP53 mutations by using RNA-guided Cas12a2 to induce chromatin shredding through targeting cancer-specific transcripts.

7 citationstop 1%

humangenetic perturbation / CRISPR

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