Chenglong Xia

Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding

This paper develops a method to selectively kill cancer cells with TP53 mutations by using RNA-guided Cas12a2 to induce chromatin shredding through targeting cancer-specific transcripts.

Single-molecule live-cell RNA imaging with CRISPR-Csm

This paper introduces smLiveFISH, a method for single-molecule live-cell imaging of endogenous RNA using CRISPR-Csm, and identifies two distinct mRNA localization mechanisms.

Proteomic and functional analyses of the periodic membrane skeleton in neurons

The paper identifies and validates MPS-interacting proteins in neurons, showing their periodic distribution and functional roles in axon interactions and diameter regulation.

Conservation and divergence in cortical cellular organization between human and mouse revealed by single-cell transcriptome imaging

This study compares cellular organization and interactions in human and mouse cortex using single-cell transcriptome imaging, finding conserved laminar organization but divergent cell-cell interactions in humans.