Author

Arushi Singhal

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Aashish ManglikiD· 1 shared Alan AshworthiD· 1 shared Chenglong XiaiD· 1 shared Christian B. BillesbølleiD· 1 shared Chun YeiD· 1 shared Daniel Rosas-Rivera· 1 shared Erick LuiD· 1 shared Finn D. WolfreysiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenomics

Aashish ManglikORCID

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2 papers

Recent·Most cited

Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding

Jingkun Zeng, Zhiyuan Cheng, Huadong Chen, Zhaojun Wang, Jared Thompson, Kadin T. Crosby, Hesong Han, Arushi Singhal, Wayne Ngo, Chenglong Xia, Daniel Rosas-Rivera, Zeyuan Terry Zhang, Min Hyung Kang, Ying Mao, Morgan E. Diolaiti, , Jennifer A. Doudna

This paper develops a method to selectively kill cancer cells with TP53 mutations by using RNA-guided Cas12a2 to induce chromatin shredding through targeting cancer-specific transcripts.

Nature · Jun 8, 2026Peer-reviewedCell Biology

Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8

Taylor N. LaFlam, Christian B. Billesbølle, Tuan Dinh, Finn D. Wolfreys, Erick Lu, Tomas Matteson, Jinping An, Ying Xu, Arushi Singhal, Nadav Brandes, Vasilis Ntranos, Aashish Manglik, Jason G. Cyster, Chun Ye

The paper uses deep mutational scanning and structural analysis to study the functional effects of missense variants in the P2RY8 receptor and improves variant effect predictions.

Cell Genomics · Sep 11, 2025Peer-reviewedGenomics