Weizhe Chen

This study evaluates how guide RNA multiplexing and target site selection affect homing gene drive efficiency in Drosophila suzukii, showing that germline context and design choices significantly influence performance.

This study shows that CRISPR-based gene drives producing dominant female-sterile alleles can enhance population suppression by increasing elimination rates and reducing chasing dynamics.

This study evaluates strategies to improve homing gene drive efficiency using multiplexed gRNAs, finding that population-level multiplexing enhances drive efficiency despite increased vulnerability to resistance.

The paper correlates single-cell transcriptome data with gene drive performance by analyzing Cas9 promoter expression in different systems.

This study demonstrates daisy chain gene drives in Drosophila and models their population dynamics, finding they can eliminate populations but face challenges in efficiency and spread.

This paper describes a gene drive targeting doublesex in Drosophila that generates dominant female-sterile resistance alleles, leading to stronger population suppression in computational models.

The paper describes a gene drive system called RIDD that suppresses Drosophila populations by inducing sterility in females through a dominant sterile homing drive targeting doublesex.

The paper identifies new germline Cas9 promoters in Drosophila that improve drive conversion efficiency while reducing embryo resistance and somatic expression.