Matthew Metzloff

The paper identifies new germline Cas9 promoters in Drosophila that improve drive conversion efficiency while reducing embryo resistance and somatic expression.

This paper develops a homing suppression gene drive in Drosophila using multiplexed gRNAs to prevent resistance alleles, achieving high conversion efficiency and moderate population suppression.

This paper demonstrates a tethered gene drive system in Drosophila that confines homing drives to target populations, enabling controlled modification or suppression.