Jamie L McCuiston

This study shows that PBRM1 in PBAF is essential for EMT and metastasis in breast cancer by enabling promoter targeting and DNA accessibility for TGFβ1-inducible genes.

This study uses single-nucleus multiome sequencing and spatial transcriptomics to analyze liposarcoma subtypes, revealing distinct cellular states, immune features, and gene regulatory circuits.

The paper investigates how nucleosome context influences chromatin reader binding preferences using biochemical and genomic approaches, revealing that multivalent engagement often has regulatory effects beyond simple additivity.

The paper identifies a critical binding interface in DNMT3A1 that facilitates DNA hypermethylation at Polycomb target genes by recognizing H2AK119Ub and the nucleosome acidic patch.