Roman Liebe

Transient suppression of the ECM1 gatekeeper is essential for HGF/c-MET-driven liver regeneration

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma

The paper identifies a YB-1-mA-DNMT regulatory axis that drives cisplatin resistance in iCCA by promoting ABCB1 expression through promoter demethylation.

TGF-β serves as a critical signaling determinant of liver progenitor cell fate and function

This study identifies TGF-β as a key regulator of liver progenitor cell quiescence and activation, showing its dual role in inhibiting proliferation while being counteracted by HGF and EGF signals.

Regulation of essential hepatocyte functions and identity by super-enhancers in health and disease

This study identifies super-enhancers as critical regulators of liver function genes in hepatocytes and liver progenitor cells during health and acute liver failure.

FOXA2 is essential for maintaining the urea cycle in acute liver failure

This study identifies FOXA2's role in maintaining urea cycle function in acute liver failure by regulating CPS1 transcription and preventing hyperammonemia.

Rapid dexamethasone treatment inhibits LPS-induced cytokine storm in mice

This study shows that rapid dexamethasone treatment inhibits LPS-induced cytokine storm in mice by blocking RNA Pol II activity in pre-loaded pro-inflammatory genes.