Author

Sebastian Gaese

Brigham and Women's HospitalORCID 0009-0001-0375-3214Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Abigail UchiteleviD· 1 shared Alain NdayisabaiD· 1 shared Alice BuonfiglioliiD· 1 shared Ashley HarlockiD· 1 shared Braxton Riley SchuldtiD· 1 shared Camille GoldmaniD· 1 shared Dimitrios KyriakisiD· 1 shared Donghoon LeeiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Abigail UchitelevORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintFeb 9, 2025

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model

Louise Alessandra Mesentier-Louro, Camille Goldman, Sebastian Gaese…·Joel Blanchard

This study develops a human brain tissue model (miBrain) to show that APOE4 astrocytes with cholesterol dysregulation promote α-synuclein pathology through endolysosomal dysfunction.

4 citations

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