Dimitrios Kyriakis

This study identifies ZFHX4 as a key regulator of midbrain dopaminergic neuron differentiation by controlling cell cycle progression through the LIN28A-miR-9 axis.

This study develops a human brain tissue model (miBrain) to show that APOE4 astrocytes with cholesterol dysregulation promote α-synuclein pathology through endolysosomal dysfunction.

The paper integrates scRNA-seq time series data with molecular networks to identify PD-related genes and potential drug targets.

This study shows that Rac1 and Rac3 are essential for cortical interneuron migration and axon growth, with TPC2 contributing to the phenotype by affecting axonogenesis and migration.