Author

Ashley Harlock

Icahn School of Medicine at Mount SinaiORCID 0009-0009-6779-526XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Braxton Riley SchuldtiD· 2 shared Joel BlanchardiD· 2 shared Abigail UchiteleviD· 1 shared Alain NdayisabaiD· 1 shared Alice BuonfiglioliiD· 1 shared Alison GoateiD· 1 shared Ana C. PereiraiD· 1 shared Andrea Pérez ArévaloiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Braxton Riley SchuldtORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 4, 2025

APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transition

Braxton Riley Schuldt, Dominic Haworth-Staines, Andrea Pérez Arévalo…·Joel Blanchard

This study identifies APOE4-driven pericyte-to-myofibroblast transition in cerebrovascular disease, leading to fibrosis and amyloid deposition, and shows TGF-β inhibition can reverse these effects.

2 citations

humanscRNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 9, 2025

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model

Louise Alessandra Mesentier-Louro, Camille Goldman, Sebastian Gaese…·Joel Blanchard

This study develops a human brain tissue model (miBrain) to show that APOE4 astrocytes with cholesterol dysregulation promote α-synuclein pathology through endolysosomal dysfunction.

4 citations

humanscRNA-seq

𝕏 PostBluesky