Author

Braxton Riley Schuldt

Icahn School of Medicine at Mount SinaiORCID 0000-0002-1737-707XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Joel W. BlanchardiD· 3 shared Ashley HarlockiD· 2 shared Camille GoldmaniD· 2 shared Abhishek SahasrabudheiD· 1 shared Abigail UchiteleviD· 1 shared Alain NdayisabaiD· 1 shared Alice BuonfiglioliiD· 1 shared Alison GoateiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersNeuroscience

Joel W. BlanchardORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 4, 2025

APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transition

Braxton Riley Schuldt, Dominic Haworth-Staines, Andrea Pérez Arévalo…·Joel Blanchard

This study identifies APOE4-driven pericyte-to-myofibroblast transition in cerebrovascular disease, leading to fibrosis and amyloid deposition, and shows TGF-β inhibition can reverse these effects.

2 citations

humanscRNA-seq

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Cell BiologyiSciencePeer-reviewedJun 3, 2025

Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout

Camille Goldman, Tatyana Kareva, Lily Sarrafha…·Joel W. Blanchard

The paper develops GEM-SCOPe, a modular fluorescent tool to study lysosomal and mitochondrial dysfunction in Parkinson's disease, identifying disease-related changes in organelle behavior.

4 citations

humanimaging

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NeurosciencebioRxivPreprintFeb 9, 2025

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model

Louise Alessandra Mesentier-Louro, Camille Goldman, Sebastian Gaese…·Joel Blanchard

This study develops a human brain tissue model (miBrain) to show that APOE4 astrocytes with cholesterol dysregulation promote α-synuclein pathology through endolysosomal dysfunction.

4 citations

humanscRNA-seq

𝕏 PostBluesky