Sophie Simard

The paper investigates BMAL1 expression in human and mouse microglia using multiple methods and finds minimal or absent expression, with epigenetic factors likely suppressing it.

The paper investigates how childhood abuse affects microglial markers and perineuronal nets in the ventromedial prefrontal cortex of individuals who died by suicide.

The paper uses spatial transcriptomics and FISH to analyze adult hippocampal neurogenesis in the human dentate gyrus across ages, finding few neural stem cell markers but significant DCX expression with mixed inhibitory and excitatory phenotypes.

This study shows that early-life stress alters microglial transcriptome and function in mice, affecting phagocytic capacity and gene expression in adulthood.