Author

David B Graf

University of KentuckyORCID 0009-0001-3198-9865Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alan DaughertyiD· 2 shared Hisashi SawadaiD· 2 shared Hong S. LuiD· 2 shared Jessica J. MoorlegheniD· 2 shared Sohei ItoiD· 2 shared Alex C. PetteyiD· 1 shared Bryana M. LevitaniD· 1 shared Chen ZhangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPathology

Alan DaughertyORCID

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2 papers

Recent·Most cited

Cardiac Hemorrhage Precedes Hypertension-induced Fibrosis inPlasminogen Activator Inhibitor-1 Deficient Mice

Alex C. Pettey, Sohei Ito, Michael Franklin, Deborah A. Howatt, Jessica J. Moorleghen, Bryana M. Levitan, David B Graf, Valerie Z Guzmán, Nancy Zhang, Daniel A Lawrence, Thomas H Sisson, Hisashi Sawada, Jeffrey E. Saffitz, Hong S. Lu, Alan Daugherty

This study shows that PAI-1 deficiency leads to early cardiac hemorrhage and fibrosis under hemodynamic stress, with mutations in the protease-inhibitory domain causing similar pathology.

Cardiovascular Research · Oct 27, 2026Peer-reviewedPathology

Smooth Muscle Cells and Fibroblasts in the Proximal Thoracic Aorta Exhibit Minor Differences Between Embryonic Origins in Angiotensin II-driven Transcriptional Alterations

Sohei Ito, David B Graf, Yuriko Katsumata, Jessica J. Moorleghen, Chen Zhang, Yanming Li, Scott A. LeMaire, Ying H. Shen, Hong S. Lu, Alan Daugherty, Hisashi Sawada

The paper examines transcriptomic changes in smooth muscle cells and fibroblasts from different embryonic origins in the proximal thoracic aorta under AngII infusion, finding modest differences between origins.

bioRxiv · Jan 23, 2025 · PreprintPathology