Cycling persister clones with elevated NR2F1-mediated cholesterol biosynthesis cause chemotherapy resistance
Hajime Sato, Taku Sato, Yohei Sasagawa, Ryoko Seki, Shicheng Zhang, Hiroshi Haeno, Daisuke Hishikawa, Mashito Sakai, Kenta Hata, Itoshi Nikaido, Yoshiyuki Mori, Tadahide Noguchi, Toshiaki Ohteki
The paper identifies cycling persisters (CPs) in cancer organoids and shows that elevated NR2F1-mediated cholesterol biosynthesis contributes to chemotherapy resistance.
bioRxiv · Jun 10, 2026 · PreprintCancer Biology