Mashito Sakai

This study identifies age-related erosion of organ-specific endothelial programs and links it to tissue dysfunction across multiple organs.

The paper identifies cycling persisters (CPs) in cancer organoids and shows that elevated NR2F1-mediated cholesterol biosynthesis contributes to chemotherapy resistance.

The paper analyzes how genetic variation affects gene expression and epigenetics in Kupffer cells, distinguishing between cell intrinsic and environment-dependent mechanisms.

The paper systematically analyzes naturally occurring insertions and deletions (InDels) to assess their impact on transcription factor spacing and identifies tolerant and sensitive TF pairs.

The paper identifies non-redundant DNA binding activities of AP-1 family members in macrophages using ChIP-sequencing and machine learning, showing motif ensembles drive factor-specific binding.