Zhijian Zhang

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

This study uses temporal multi-modal single-cell profiling to show CAR-T cells interact dynamically with glioblastoma cells, including antigen-negative ones, and reduce their proliferation through IFN-gamma.

Presynaptic NMDA receptors control CCK release from entorhinal neurons, enabling neocortical LTP and sound-sound associative memory.