Author

Daniel Y. Zhang

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Guo‐li MingiD· 3 shared Hongjun SongiD· 3 shared Donald M. O’RourkeiD· 2 shared Fadi JacobiD· 2 shared MacLean P. NasrallahiD· 2 shared Yusha Y. SuniD· 2 shared Zev A. BinderiD· 2 shared Anne G. BangiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

Guo‐li MingORCID

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Author profile →

3 papers

Recent·Most cited

Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy

Meghan T. Logun, Xin Wang, Yusha Y. Sun, Stephen Joseph Bagley, Nannan Li, Arati Suvas Desai, Daniel Y. Zhang, MacLean P. Nasrallah, Emily Ling-Lin Pai, Bike Su Oner, Gabriela Plesa, Don L. Siegel, Zev A. Binder, Guo‐li Ming, Hongjun Song, Donald M. O’Rourke

The paper shows that patient-derived glioblastoma organoids can reflect CAR-T cell treatment responses in real-time, correlating with clinical outcomes in patients.

Cell stem cell · Dec 9, 2024Peer-reviewedCancer Biology

Temporal multi-modal single-cell analyses reveal dynamic interactions of CAR-T cells with glioblastoma and targeting of antigen-negative neoplastic cells

Daniel Y. Zhang, Xin Wang, Yusha Y. Sun, Qi Cui, Ernest J Nelson, Zhijian Zhang, Brian L. Huang, Josephine Ruth Giles, Radhika Thokala, Daniel R. Connolly, Fadi Jacob, E. John Wherry, Timothy Lucas, Han-Chiao Isaac Chen, Yanhong Shi, , Hongjun Song

This study uses temporal multi-modal single-cell profiling to show CAR-T cells interact dynamically with glioblastoma cells, including antigen-negative ones, and reduce their proliferation through IFN-gamma.

bioRxiv · Oct 3, 2024 · PreprintCancer Biology

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

Fadi Jacob, Sarshan R. Pather, Wei‐Kai Huang, Feng Zhang, Samuel Zheng Hao Wong, Haowen Zhou, Beatrice Cubitt, Wenqiang Fan, Catherine Z. Chen, Miao Xu, Manisha Pradhan, Daniel Y. Zhang, Wei Zheng, Anne G. Bang, Hongjun Song, , Guo‐li Ming

This study shows SARS-CoV-2 can infect brain cells and organoids derived from human induced pluripotent stem cells, leading to cell death and inflammation, and suggests using these models to study the virus's effects on the brain.

Cell stem cell · Sep 21, 2020Peer-reviewedNeuroscience