Fuqiang Xu

An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish

This paper develops an efficient method for retrograde monosynaptic tracing in larval zebrafish neural circuits using modified rabies viruses.

AAV11 mediates efficient retrograde trans-neuronal transduction of astrocytes

This paper demonstrates that AAV11 enables retrograde trans-neuronal transduction of astrocytes, providing a tool to study astrocyte-neuron connectivity networks.

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution

This paper presents a high-speed imaging system for whole-mouse peripheral nerve mapping at subcellular resolution, revealing detailed neural projections and patterns.

Neural Circuit Underlying Individual differences in Visual Escape Habituation

The paper identifies two distinct visual escape behaviors and their neural pathways, revealing how the mediodorsal thalamus modulates arousal and defensive responses to repeated threats.

Cell-type-specific striatal modulation of amygdalar acetylcholine in salience assignment

The paper shows striatal D1 and D2 MSNs regulate BLA ACh levels, influencing salience assignment through distinct mechanisms.

Microglia-specific transduction via AAV11 armed with IBA1 promoter and miRNA-9 targeting sequences

This paper evaluates AAV11 vectors with IBA1 promoter and miRNA-9 sequences for microglia-specific transduction, finding AAV11 provides high specificity and efficiency in transducing microglia across brain regions and spinal cord.

AAV11 permits efficient retrograde targeting of projection neurons

The paper identifies rAAV11 as a highly efficient retrograde tracer for projection neurons, with improved transduction and utility for neural circuit monitoring and astrocyte targeting.

Dopamine modulates visual threat processing in the superior colliculus via D2 receptors

This study shows that D2 dopamine receptors in the superior colliculus modulate defensive behaviors to visual threats, with optogenetic activation promoting defensive responses and chemogenetic inhibition reducing them.

Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution: relevance to diffusion tractography

The paper maps excitatory axonal projections from the macaque ventrolateral prefrontal cortex to the whole brain at submicron resolution, revealing discrepancies with diffusion tractography.

Improved production and expanded application of CVS-N2c-ΔG virus for retrograde tracing

The paper improves the production of CVS-N2c-ΔG virus for retrograde tracing, showing higher efficiency and broader application in neural circuit studies.

High-throughput whole-brain mapping of rhesus monkey at micron resolution

This paper develops a high-throughput method for whole-brain imaging of rhesus monkeys at high resolution, enabling detailed connectome mapping of axonal fibers.

Rigorous anterograde trans-monosynaptic tracing of genetic defined neurons with retargeted HSV1 H129

This paper describes a retargeted HSV1 H129 system for anterograde trans-monosynaptic tracing of genetically defined neurons, enabling precise mapping of neural circuits.

A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety

The paper identifies a novel GABAergic projection from the BNST to accumbal parvalbumin neurons that modulates anxiety-related behavior through inhibitory synaptic transmission.

Highly efficient and super-bright neurocircuit tracing using vector mixing-based virus cocktail

This paper introduces MAP-ENVIVIDERS, a vector mixing-based virus cocktail that significantly improves neurocircuit tracing efficiency and sensitivity compared to existing methods.

Superior Colliculus-Projecting GABAergic Retinal Ganglion Cells Mediate Looming-Evoked Flight Response

This study identifies superior colliculus-projecting GABAergic retinal ganglion cells as mediators of looming-evoked flight response by inhibiting SC neurons via GABA.

A VTA GABAergic neural circuit mediates visually evoked innate defensive responses

This study identifies VTA GABAergic neurons as critical for visually evoked innate defensive behaviors in mice.

Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution

This paper introduces a light-sheet microscopy method for fast, large-scale volumetric brain imaging at synaptic resolution, achieving whole mouse brain scans in 2 hours.

Dense reconstruction of brain-wide neuronal population close to the ground truth

The paper develops a tool for fast and accurate reconstruction of neuronal populations in large brain datasets, achieving results close to ground truth with high automation.

Unconsciously Implanted Visuoauditory Memory in the Presence of Cholecystokinin Retrieved in Behavioral Contexts

This study shows that visuoauditory associations can be artificially implanted in rodents and retrieved in behavioral contexts, with cholecystokinin (CCK) playing a critical role in this process.

A cortical pathway modulates sensory input into the olfactory striatum

This study investigates the functional role of the cortico-striatal pathway from the piriform cortex to the olfactory tubercle in mice, showing it modulates odor coding through monosynaptic connections.

Cholecystokinin release triggered by presynaptic NMDA receptors produces LTP and sound-sound associative memory formation

Presynaptic NMDA receptors control CCK release from entorhinal neurons, enabling neocortical LTP and sound-sound associative memory.