Author

Sanne de Haan

Oncode InstituteORCID 0009-0001-6713-229XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Anna C. ObenaufiD· 1 shared Anna Dyas· 1 shared Cissy YongiD· 1 shared Daniel Muñoz‐EspíniD· 1 shared Grant Duncan StewartiD· 1 shared Jarno DrostiD· 1 shared Jianfeng GeiD· 1 shared Leticia CastilloniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Anna C. ObenaufORCID

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1 paper

Recent·Most cited

Cancer BiologyEMBO Molecular MedicinePeer-reviewedDec 19, 2025

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities

Jianfeng Ge, Shoko Hirosue, Leticia Castillon…·Sakari Vanharanta

This study identifies HIF1A as a key inhibitor of VHL null cell fitness and shows that combined VHL/HIF1A inactivation can confer resistance to PROTAC-based therapies.

3 citations

humangenetic perturbation / CRISPR

𝕏 PostBluesky