Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities
Jianfeng Ge, Shoko Hirosue, Leticia Castillon, Saroor A. Patel, Ludovic Wesolowski, Anna Dyas, Cissy Yong, Sanne de Haan, Jarno Drost, Grant Duncan Stewart, Anna C. Obenauf, Daniel Muñoz‐Espín, Sakari Vanharanta
This study identifies HIF1A as a key inhibitor of VHL null cell fitness and shows that combined VHL/HIF1A inactivation can confer resistance to PROTAC-based therapies.
EMBO Molecular Medicine · Dec 19, 2025Peer-reviewedCancer Biology